腰部多体的结构和功能差异与女性非特异性腰部疼痛的结构性脑形态之间的关系:一项观察性研究
Rahmat Adnan1,2, Evy Dhondt1,3, Lieven Danneels1
1Spine, Head and Pain Research Unit Ghent, Department of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
PloS one
|December 2, 2025
概括
这项研究将腰部多筋 (LM) 肌肉结构和功能与大脑灰色物质在非特异性腰部疼痛 (NSLBP) 患者和健康对照者 (HCs) 的感觉运动区域的变化联系起来. 这些发现突出了改变的LM影响大脑结构.
科学领域:
- 神经科学是一个神经科学.
- 肌肉骨成像系统的成像
- 放射学 放射学是一门学科.
背景情况:
- 腰部多筋 (LM) 肌肉特征与感觉运动区域的大脑灰质变化之间的关系在患有和没有非特异性腰部疼痛 (NSLBP) 的人中仍未被探索.
- 了解这些联系对于全面了解腰部疼痛病理生理学和感觉运动控制至关重要.
研究的目的:
- 调查LM形态和功能和灰色物质厚度 (GMT) 和灰色物质体积 (GMV) 在感觉运动皮层区域之间的关联.
- 为了比较NSLBP患者和健康对照 (HC) 患者的这些关系.
主要方法:
- 用T1加权的迪克森成像来评估腰部多体 (LM) 形态 (横截面积,肌肉脂肪指数).
- 使用肌肉功能性MRI (mfMRI) 评估LM功能 (T2-休息,T2-转移).
- 皮层灰色物质厚度 (GMT) 和体积 (GMV) 来自高分辨率T1加权图像,并使用线性混合模型进行分析.
主要成果:
- 在偏中心和后中心皮层中,LM肌肉脂肪指数和GMV之间发现了积极的关联,独立于腰部疼痛 (LBP).
- 脊髓肌肉T2-rest在各种传感运动区域,包括额叶,顶叶和带膜皮层,与GMT和GMV有积极的关联.
- 在特定皮质区域观察到LM T2-shift和GMT/GMV之间的负相关性,表明改变的肌肉功能与大脑结构变化相关.
结论:
- 改变的LM结构和功能与感觉运动皮质区域的灰色物质结构性质有关.
- 这些发现强调了腰部多体和大脑结构适应之间的潜在联系,这与NSLBP和健康个体相关.
相关概念视频
01:30General Structure of a Vertebra
7.5K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
7.5K
01:16Spinal Cord: Cross-sectional Anatomy
5.7K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
5.7K
01:29Herniated Intervertebral Disc l: Introduction
40
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
40
01:27Degenerative Disc Disease I: Introduction
29
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
29