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Updated: Jan 9, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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通过KLHDC2 E3 Ubiquitin Ligase进行选择性CDK6降解

Eunhye Jeon1,2, Younghoon Kim1, Hyunwoo Ahn3

  • 1Department of Biomedical Sciences, Graduate School of Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Journal of medicinal chemistry
|December 2, 2025
PubMed
概括

研究人员开发了针对KLHDC2的新型小分子配体,以创建有选择性的CDK6降解剂. 降解剂48a有效地降低了白血病细胞和瘤中的CDK6,显示了针对向蛋白质降解的治疗潜力.

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