在接受暴露前预防治疗 (PrEP) 以预防艾滋病毒的患者中,帕斯普拉纳视切除术后视网膜光毒性
Elisa Cozzi1, Matteo Giuseppe Cereda1, Clarissa Giannini2
1Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Italy.
Retinal cases & brief reports
|December 2, 2025
概括
本案例报告强调了HIV暴露前预防 (PrEP) 药物治疗的患者潜在的视网膜光毒性,该患者正在接受帕斯普拉纳视切除术. 在手术期间减少光线暴露对于服用光敏剂的患者可能是必要的.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜外科手术 视网膜外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕斯普拉纳玻璃切除术是一种常见的外科手术程序.
- 暴露前预防 (PrEP) 用于预防艾滋病毒.
- 系统性药物可能会对眼部产生副作用.
研究的目的:
- 报告一个疑似视网膜光毒性的病例,在帕斯普拉纳视体切除术后.
- 研究暴露前预防 (PrEP) 在光敏化中的潜在作用.
- 提高对照明敏感药物患者的视网膜损伤的认识.
主要方法:
- 一个45岁的男性患者的回顾性病例报告.
- 对玻璃体出血和视网膜断裂进行Pars plana玻璃切除术.
- 使用标准的内光照明;没有使用重要染料.
- 光学相干断层扫描 (OCT) 和蓝色底部自光学用于监测.
主要成果:
- 手术后的OCT和自光检测显示了对状外视网膜破坏和RPE斑点.
- 在照亮的手术区域内观察到圆形区域的不连续性.
- 视力敏度在六个月后改善到20/25 ,并持续出现RPE变化.
结论:
- 外视网膜变化表明,由PrEP诱导的光敏化增强的光化学损伤.
- 这一案例强调了在接受光敏感药物治疗的患者中,在玻璃切除术期间存在光毒性风险.
- 需要新的策略来尽量减少这些患者在手术期间的光线暴露.
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