台湾的SARS-CoV-2小微型亚变体的基因组进化和流行病学影响,2023-2025年
Li-Teh Liu1, Chao-Ju Chen2, Po-Chih Chen3
1Department of Medical Laboratory Science and Biotechnology, College of Medical Technology, Chung Hwa University of Medical Technology, Tainan City, Taiwan.
Journal of infection and public health
|December 2, 2025
概括
在台湾,SARS-CoV-2 Omicron 变种在动态发展,JN.1 及其后代成为主导. 病例定义的变化对报告的COVID-19趋势产生了重大影响,突出显示了对强有力的监测的需要.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- SARS-CoV-2 Omicron 子系的持续演变需要持续的基因组和流行病学监测.
- 从2023年11月到2025年2月,台湾的SARS-CoV-2景观被检查了基因组,国家和临床趋势.
研究的目的:
- 调查台湾SARS-CoV-2的基因组流行病学和国家趋势.
- 分析临床方面和Omicron亚变体分布,包括XBB.1.5和JN.1疫苗的影响.
主要方法:
- 分析局部队列 (n=22) 的分子和临床特征.
- 评估全国病例和死亡率趋势,使用监测数据和修订的病例定义.
- 来自GISAID的1782个台湾序列的基因组监测,以追踪Omicron亚变体的演变.
主要成果:
- JN.1及其后代取代了XBB亚变体,在2024年初/中期引发了感染浪潮.
- 在2024年9月对严重COVID-19的更严格的国家病例定义改变了指标,减少了报告的病例,但增加了死亡率.
- 在全国范围内,65岁以上的伴随疾病和低疫苗接种覆盖率的个人面临严重后果的风险增加.
结论:
- 台湾的动态SARS-CoV-2 Omicron进化被JN.1衍生品主导,导致连续的感染波.
- 国家病例定义的变化创造了监测人工物,使疾病负担的解释复杂化.
- 高龄仍然是严重COVID-19的关键风险因素,强调有针对性的疫苗接种和综合监测.
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