新兴的沙门氏菌 (Salmonella enterica serovar Infantis) 形成了一个由地理结构塑造的单系血统
Alejandro Piña-Iturbe1, Daniel Tichy-Navarro2, Josefina Miranda-Riveros1
1Escuela de Medicina Veterinaria; Facultad de Agronomía y Sistemas Naturales, Facultad de Ciencias Biológicas y Facultad de Medicina; Pontificia Universidad Católica de Chile; Santiago; Chile.
International journal of food microbiology
|December 2, 2025
概括
耐多药沙门氏菌,一个全球性公共卫生威胁,已经在全球范围内蔓延. 基因组分析揭示了它的起源,地理传播和抗生素耐药性基因的传播,突出了综合监测的必要性.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 携带类似pESI的大质粒体的多药耐药沙门氏菌是全球日益严重的公共卫生问题.
- 以前的人口结构和时间动态研究受到小数据集和抽样偏差的限制.
研究的目的:
- 描述全球人口结构和萨尔门氏菌的生物地理分布.
- 分析所有公开可用的Salmonella Infantis基因组,以克服先前研究的局限性.
主要方法:
- 对14010个沙门氏菌Infantis基因组的非冗余数据集进行了基因组学分析.
- 在1910年至2024年期间,从五大洲的77个国家收集了基因组.
主要成果:
- 新兴的大质粒阳性沙门氏菌Infantis形成了一个单系,具有独特的地理结构.
- 这个血统起源于西亚,大约在1990年,通过多次引入和传播在全球范围内传播,特别是通过美洲.
- 编码扩展光谱β-乳酸酶 (ESBLs) 的blaCTX-M-65基因的传播是由美国血统驱动的.
结论:
- 耐多药沙门氏菌的全球传播与特定的血统和传播途径有关,包括国际家禽贸易.
- 对人类,动物和环境数据的综合全球监测与人口基因组分析对于控制ESBL产生的沙门氏菌至关重要.
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