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在结核病接触者与糖尿病患者之间,人类大膜巨细胞功能受损

Léanie Kleynhans1, Carine Kunsevi-Kilola2, Happy Tshivhula2

  • 1DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia.

EBioMedicine
|December 2, 2025
PubMed
概括

2型糖尿病 (T2D) 损害了对Mycobacterium tuberculosis (Mtb) 的早期人膜巨细胞 (HAM) 反应,增加了Mtb的生长. 这种糖尿病HAM表型涉及延迟基因表达,表观遗传变化和减少中性粒细胞的招募,解释了T2D患者的结核病风险增加.

关键词:
膜细胞巨细胞.支气管气管洗是一种支气管气管洗.单细胞衍生的巨细胞.菌根菌的生长 菌根菌生长结核病是一种疾病.2 型糖尿病 2 型糖尿病

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