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Updated: Jan 9, 2026

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发现imidazo[1,2-a]pyridine衍生物作为强大的抗流感剂:基于SPR亲和力的查和结构-活性关系研究

Chao Zhang1, Yun-Sang Tang2, Jian-Fei Gao1

  • 1Key Laboratory of Structure-based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, 110016, China.

European journal of medicinal chemistry
|December 2, 2025
PubMed
概括

新的imidazo[1,2-a]pyridine化合物有效地抑制了流感A病毒的RNA依赖RNA聚合酶 (RdRp). 化合物41显示出强大的,广泛的抗病毒活性和稳定的结合,突出显示出一个有前途的RdRp抑制策略.

关键词:
抗病毒剂是一种抗病毒剂.伊米达佐[1,2-a]氨酸是什么流感病毒是流感病毒.PA-PB1 接口的接口是 PA-PB1 的接口.RNA聚合酶抑制剂RNA聚合酶抑制剂结构与活动的关系.

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