严重的COVID-19,疫苗接种和患有喘的人群死亡率:全国基于人口的队列研究
Sang Hyuk Kim1, Min Gu Kang2, Jong Geol Jang3
1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea; Department of Medicine, Korea University Graduate School of Medicine, Seoul, Republic of Korea.
Vaccine
|December 2, 2025
概括
接种COVID-19疫苗显著降低了喘患者的长期死亡率,即使是那些感染了病毒的人. 这一发现强调了疫苗接种对喘患者的保护性益处.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 患有喘的人面临来自严重COVID-19的较高死亡风险.
- COVID-19疫苗接种对喘患者死亡率的长期影响尚不清楚.
研究的目的:
- 研究COVID-19疫苗接种与喘患者的长期全因死亡率之间的关联.
- 在喘患者中比较不同疫苗接种和感染状态的死亡率.
主要方法:
- 利用韩国国家健康保险系统数据库对3384名患有喘的人群进行了分析.
- 员工倾向性得分匹配将参与者分为四组:接种疫苗/未感染者,接种疫苗/感染者,未接种疫苗/未感染者和未接种疫苗/感染者.
- 用两个具有不同参考组的多变量模型分析了全因死亡率.
主要成果:
- 接种疫苗和未感染的个体的死亡率最低 (94人/10,000人年).
- 接种COVID-19疫苗与严重的COVID-19病例死亡率减少61%有关.
- 接种疫苗还使未感染个体的死亡风险降低了74%,而严重的COVID-19感染显著增加了死亡风险.
结论:
- 接种COVID-19疫苗与喘患者的长期死亡率降低有关.
- 无论COVID-19感染状况如何,都观察到接种疫苗的保护作用.
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