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在口腔癌中准TRP通道:机制潜力和治疗前景

Kaviyarasi Renu¹, Vishnu Priya Veeraraghavan¹, Harishkumar Madhyastha²

¹Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Seminars in oncology

|December 2, 2025

概括

暂时受体潜力 (TRP) 道在口腔癌的发展中起着关键作用. 针对这些通道提供了一个有前途的新策略,用于治疗口腔癌.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
信号传递信号传递

背景情况:

口腔癌带来了重大的临床挑战,患者预后不佳.
有限的治疗选择需要识别新的分子标.
(Ca2+) 离子通道,特别是短暂受体潜力 (TRP) 通道,与癌症进展有关.

研究的目的:

系统地审查特定TRP通道在口腔癌发病和进展中的作用.
检查口腔状细胞癌 (OSCC) 中TRP通道的失调表达和功能.
探索针对TRP通道在口腔癌管理中的治疗潜力.

主要方法:

在Scopus,Embase,Web of Science和Google Scholar中进行全面的文献搜索,直到2025年1月.
专注于TRPA1,TRPV1-4,TRPM2,TRPM6和TRPM8频道. 这些频道包括:
在OSCC中对TRP通道表达,功能和下游信号的研究分析.

主要成果:

异常的TRP通道活性与增加的口腔癌细胞增殖,迁移,入侵和生存有关.
TRP通道调节信号通路,这对于口腔致癌至关重要.
TRP通道,信号传递和瘤源途径 (PI3K/AKT,MAPK) 之间的相互作用影响瘤行为.

结论:

TRP通道是口腔致癌的关键参与者.
准TRP道代表了口腔癌的新疗法策略.
对通道蛋白相互作用和选择性TRP抑制剂的进一步研究是有必要的.

关键词:

离子是一种离子.癌症癌症癌症癌症这是OSCCCC的OSCC.口腔癌是一种口腔癌.在 TRP 频道.

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