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基托桑基抗菌血静性海绵用于抗凝剂患者无法控制的拔牙出血

Rongxia Tang¹, Lu Zheng², Shangfei Chi³

¹Department of Stomatology, Guangdong Provincial People's Hospital's Nanhai Hospital, Foshan 528200, China; Department of stomatology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Colloids and surfaces. B, Biointerfaces

|December 2, 2025

概括

一种新的静血海绵 (QCD) 在接受抗凝剂治疗的患者中有效地阻止了牙拔除后的出血. 这种先进的材料与传统的凝海绵相比,提供了更高的性能,减少了血液流失和感染风险.

科学领域:

生物材料科学生物材料科学
牙科手术牙科手术
血液静止研究血液静止研究

背景情况:

抗凝固药物治疗通过损害自然血液静止增加了提取后出血风险.
治疗抗凝血剂患者的出血是一个重大的临床挑战.
现有的静血剂在有效性和感染控制方面可能存在局限性.

研究的目的:

开发和评估一种新型的四元化碳甲基/多多巴胺复合血静海绵 (QCD).
在体外和体内评估QCD海绵的静血和抗菌特性.
为了比较QCD与商用凝海绵的性能,用于管理提取后出血.

主要方法:

制造一个四分制的碳氧甲基基托/多多巴胺复合血静海绵 (QCD).
在体外评估静血和抗菌功效.
在体内评估使用抗凝血小鼠的牙提取模型.
血液损失和静血时间与商用凝海绵进行比较.

主要成果:

与凝组相比,QCD在体外表现出更好的静血和抗菌性能.
四级氨基修饰提供了强大的抗菌活性,减轻了感染风险.
在体内,QCD在减少血液损失 (0.011 ± 0.001 g vs 0.019 ± 0.001 g) 和缩短静血时间 (59.7 ± 4.2 秒 vs 87.0 ± 4.1 秒) 方面显著优于商业凝海绵.
QCD的优势归因于血液的快速吸收和血液细胞和血小板的增强粘附,促进血块的形成.

结论:

开发的QCD静血海绵表现出卓越的静血和抗菌特性.
在抗凝血动物模型中,QCD有效地管理了提取后出血.
在接受牙科手术的抗凝血药患者中,QCD为治疗出血提供了一个有前途且实用的解决方案.

关键词:

凝血障碍凝血障碍凝血障碍静血海绵是一种静血海绵.提取后出血提取后出血四元化碳氧甲基基托.

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