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饮食调节了Vibrio cholerae的殖民化和与肠道微生物群的竞争结果

Rui Liu¹, Yue Zhang¹, Siyi Ge¹

¹Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA.

Cell host & microbe

|December 2, 2025

概括

饮食蛋白质来源通过改变鞭毛调节器FlrA.影响肠道微生物群和Vibrio cholerae殖民. 这会影响VI型分泌系统,影响病原体和感染结果的交互.

科学领域:

微生物学微生物学
营养科学营养科学
传染性疾病传染性疾病

背景情况:

饮食中的宏观营养素显著影响肠道微生物群组成和肠道环境.
肠道微生物群在对病原体和感染结果的敏感性方面发挥着至关重要的作用.

研究的目的:

研究不同饮食蛋白质来源如何影响Vibrio cholerae殖民和宿主-病原体相互作用.
阐明饮食影响肠道微生物群内的病原体竞争的分子机制.

主要方法:

对各种饮食蛋白质来源的反应中Vibrio cholerae殖民的比较分析.
评估微生物群组成变化及其对病原体动态的影响.
研究V. cholerae鞭毛调节器FlrA和VI型分泌系统 (T6SS) 在饮食中介作用中的作用.

主要成果:

饮食中的蛋白质,特别是素,差异性地限制了V. cholerae的殖民.
素改变了FlrA水平,降低了T6SS表达和V. cholerae在相对Escherichia coli的竞争优势.
FlrA中的突变恢复了T6SS的表达,并消除了对V.霍乱感染和微生物群组成的饮食依赖影响.

结论:

针对蛋白质来源的饮食干预可以作为限制V. cholerae的策略.
饮食通过调节像T6SS.这样的毒性因子,对肠道微生物群中的病原体-共生相互作用产生深远的影响.

关键词:

在T6SSSS中使用.霍乱病毒病毒 (Vibrio cholerae) 是一种病毒.饮食饮食饮食饮食这就是为什么flrAA.微生物组是一个微生物组.

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