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囊性纤维化风险变体提供了对炎症性肠道疾病的保护

Mingrui Yu1, Qian Zhang2, Kai Yuan3

  • 1Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Stanley Center for Psychiatric Research, the Broad Institute of MIT and Harvard, Cambridge, MA, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Cell genomics
|December 2, 2025
PubMed
概括

囊性纤维化跨膜调节器 (CFTR) 基因中的遗传突变可以防止炎症性肠病 (IBD). 这项研究证实CFTR风险变异与IBD风险降低有关,强调需要更好的变异优先级.

关键词:
在CFTR中,CFTR是最重要的.囊性纤维化症是什么炎症性肠病是一种炎症性肠病.人口遗传学 人口遗传学保护作用保护效果变体效应预测变体效应预测

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