在心血管疾病中训练免疫力.
Niels P Riksen1, Mihai G Netea1,2, Hafid Ait-Oufella3,4
1Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, Nijmegen 6525 GA, The Netherlands.
European heart journal
|December 2, 2025
概括
训练免疫 (TRIM) 是一种超炎性免疫细胞状态,可以由心血管疾病风险因素引发. 准髓状细胞中的TRIM通路为预防和治疗心血管事件提供了一种新的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 代谢和表观遗传调节
背景情况:
- 天生的免疫力在动脉样硬化发展中起着至关重要的作用.
- 训练免疫 (TRIM) 是一种长期的超炎性免疫表型,涉及代谢和表观遗传变化.
- TRIM可以影响成熟的免疫细胞和非免疫细胞,以及造血干细胞.
研究的目的:
- 探索训练免疫 (TRIM) 在心血管疾病 (CVD) 病理生理学中的作用.
- 基于TRIM机制,识别基于心脏病预防和治疗的新药学标.
主要方法:
- 在小鼠实验研究中,通过心血管疾病风险因素研究了TRIM诱导.
- 分析细胞代谢 (糖解,谷氨酸解) 和表观遗传修饰 (基因组甲基化,乙化,乳酸化).
- 专注于骨髓中的IL-1β信号传递,作为中央TRIM的驱动器.
主要成果:
- 中心TRIM可以由各种心血管疾病风险因素引起,包括肥胖,高血糖,高血压,炎症并发症和生活方式因素.
- 诱导TRIM导致长期存在高炎症单细胞和中性粒细胞,加速动脉样硬化.
- 骨髓中的IL-1β信号传递和代谢/表观遗传重新连接是推动TRIM发展的关键机制.
结论:
- 训练有素的免疫力与心血管疾病的病理生理学有关.
- 在髓状细胞中对TRIM通路的药理定位,为心血管事件提供了一个有前途的新疗法策略.
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