怀孕期间补充,以预防高血压疾病和相关问题
Catherine A Cluver1, Christa Rohwer1, Anke C Rohwer2
1Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
The Cochrane database of systematic reviews
|December 2, 2025
概括
在怀孕期间补充几乎没有区别,以防止先兆子或早产. 来自大型试验的高确定性证据证实了这些发现,对孕产妇和新生儿死亡率产生不确定的影响.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 营养科学 营养科学
背景情况:
- 孕前是孕产妇和新生儿发病率和死亡率的重要原因之一.
- 补充在预防妊娠高血压疾病方面的有效性仍然不确定.
- 本综述是先前研究的更新,最后一次发表于2018年.
研究的目的:
- 评估怀孕期间补充对妊娠高血压疾病的影响.
- 评估相关的母亲和儿童健康结果.
- 为了比较低剂量与高剂量补充剂的效果.
主要方法:
- 包括10个随机对照试验 (RCT) 与37,504名参与者.
- 对RCT的元分析,将补充剂与安慰剂或标准护理进行比较.
- 使用Cochrane RoB 2工具对偏差风险的评估以及使用GRADE的证据确定性.
主要成果:
- 补充剂在子前症 (低确定性证据) 中几乎没有差异,但来自大型试验的高确定性证据表明没有显著差异.
- 关于产妇死亡,副作用和新生儿死亡的证据非常不确定.
- 补充剂在围产期损失和死产中几乎没有差异,确定性中等.
结论:
- 补充与安慰剂对子宫前和早产的差异几乎没有差异,特别是在大型试验中.
- 关于严重的孕产妇发病率,新生儿死亡和不良影响的证据仍然不确定.
- 低剂量与高剂量补充剂在围产期损失和死胎等关键结果中没有显著差异.
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