"尾酒式"益生菌联合递送系统是一个多元组件策略,以克服胃肠道挑战
Xinyue Wang1, Yiyan Liu1, Rui Zhao1
1College of Food Science and Engineering, Shandong Agricultural University, Shandong Engineering Research Center of Food Nutrition and Active Health, Tai'an, 271018, PR China.
这项研究开发了一种使用碳酸和其他材料的多组分益生菌输送系统,以保护肠道中的Bifidobacterium (Bif). 该系统增强了益生菌的生存,并促进了肠道微生物群的平衡,改善了肠道健康.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 药物输送系统 药物输送系统
背景情况:
- 目前的益生菌封装方法与胃肠道的动态环境作斗争.
- 需要一个多组件的输送系统来提高益生菌的生存率和有效性.
研究的目的:
- 开发一种新的多组分益生菌口服输送系统.
- 为了提高Bifidobacterium (Bif) 在胃肠道中的稳定性和有针对性的输送.
主要方法:
- 构建了一个由碳氧甲基凝 (CMGG) /pectin (CP) 微球组成的核心,装有Bifidobacterium (Bif).
- 顺序地涂上核以素,使用酸盐 (CS) 涂上酸盐 (SA) 和碳酸 (CaCO3) 外层.
- 研究了系统的保护能力,pH反应能力和益生菌效应.
主要成果:
- 该CaCO3层提供了物理保护和中和胃酸.
- 响应pH的SA层促进了肠道释放,而CP和CS层提高了稳定性和结肠向性.
- CMGG/CP核心充当了益生菌,支持Bifidobacterium的生长,并创造了一个自我维持的系统.
- 碳氧甲基化CMGG改善了粘膜粘附和炎症向,有助于Bif的殖民.
结论:
- 多组件的输送系统显著提高了益生菌的稳定性和有针对性的殖民.
- 该系统有效地恢复肠道微生物群平衡,改善肠道健康.
- 这种方法为口服益生菌的输送提供了一个有希望的策略.
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