相关实验视频

Updated: Jan 9, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

离子液体涂层的脂质纳米颗粒显示通过红细胞的车活动,延长了血液循环和大脑吸收

Purva Khare¹, Sara X Edgecomb², Christine M Hamadani²

¹Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States of America.

Journal of controlled release : official journal of the Controlled Release Society

|December 2, 2025

概括

离子液体 (ILs) 使脂质纳米粒子 (LNPs) 能够在红细胞 (RBCs) 上车,改善大脑的传递. 这种新的LNP涂层策略增强了治疗运输到肝脏以外的具有挑战性的目标.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

脂质纳米粒子 (LNP) 对于核酸疗法至关重要,但主要向肝脏,限制其他器官的疗效.
离子液体 (ILs) 可以修改纳米粒子相互作用,潜在地改善生物分布.
之前的研究表明,ILs有助于红细胞 (RBC) 为聚合物纳米颗粒出行,减少肝脏的吸收.

研究的目的:

为了研究是否胆转基因-2-hexenoate (C2HA) 离子液体涂层可以诱导红细胞追逐脂质纳米颗粒 (LNPs) 的行程.
为了优化IL:LNP比率,增强红细胞结合和脑向.
评估IL涂层LNP的药理动力学和安全性概况.

主要方法:

用不同阴离子:阴离子比的胆转基-2-六酸盐 (C2HA) 涂层LNP.
评估红细胞结合,大脑内皮细胞和神经元中的细胞吸收.
在体内进行药理动力学和生物分布研究,并进行安全性评估.

主要成果:

优化的C2HA涂层 (1:3比) 使得LNP能够在小鼠和人类红细胞上上车.
与未涂层的LNP相比,IL涂层的LNP显示出增强的细胞吸收和显著增加的大脑输送.
IL涂层延长了循环时间,减少了肝脏吸收,并证明了有利的安全性.

结论:

离子液体涂层可以重新设计LNP,以促进红细胞车,增强大脑准.
这一战略为向具有挑战性的肝外位提供治疗方法提供了一个有前途的方法.
经IL修改的LNP代表了在克服核酸疗法输送障碍方面取得的重大进展.

关键词:

生物分布生物分布大脑输送大脑输送胆转基-2-基酸盐的使用.离子液体是一种离子液体.一个LNP就是LNP.脂质纳米颗粒的使用方法药理动力学药理动力学红细胞-搭便车旅行

更多相关视频

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Published on: April 16, 2019

相关概念视频

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...

Drug Distribution: Tissue Binding

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...