老年人心肺健康与认知之间的纵向关联:来自100代研究的10年后续研究
Ariana Nhung Le1,2, Stian Lydersen3, Daniel Estil Brissach1,4
1The Cardiac Exercise Research Group at the Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, the Norwegian University of Science and Technology.
Medicine and science in sports and exercise
|December 2, 2025
概括
在老年人中,更高的心肺呼吸能力 (CRF) 与多达五年的更好的认知能力有关. 然而,在这项研究中,一到三年的CRF变化没有影响认知功能.
科学领域:
- 老年学是一门学科.
- 认知神经科学 认知神经科学
- 运动生理学 运动生理学
背景情况:
- 心血管健康 (CRF) 已因其与老年人群认知功能的积极关联而得到认可.
- 老年人中CRF水平和认知结果之间的长期关系需要进一步研究.
研究的目的:
- 为了检查基线心肺呼吸能力 (CRF) 和老年人认知结果之间的关联.
- 研究 CRF 随着时间的推移 (1 年和 3 年) 对认知功能变化的影响.
- 在健康的老年人中探索CRF的长期认知影响.
主要方法:
- 利用了来自第100代研究的770名认知健康的老年人 (平均年龄72.0±2岁) 的数据.
- 心肺呼吸能力 (CRF) 通过氧气吸收峰值 (人体呼吸量测量) 来测量.
- 在基线后3,5年和10年使用蒙特利尔认知评估 (MoCA) 评估认知功能;线性混合模型分析了CRF和MoCA得分关系.
主要成果:
- 较高的基线CRF与3年 (β=0.06) 和5年 (β=0.07) 的改善MoCA得分相关.
- 10年后基线CRF和MoCA得分之间没有发现显著的关联.
- 无论是1年还是3年的CRF变化都没有显示出在任何评估点与MoCA分数的显著关联.
结论:
- 在1-3年内,CRF的变化与健康老年人的认知功能无关.
- 升高的基线CRF显示了持续的积极关联与认知功能长达五年.
- 在70岁之前保持高CRF水平可能对支持认知衰老至关重要.
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