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A Free-breathing fMRI Method to Study Human Olfactory Function
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[在上呼吸道感染后患有嗅觉功能障碍的患者中,对右轨道前皮层形态变化的多维MRI研究]
1Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
概括
传染后嗅觉功能障碍 (PIOD) 与右轨道前皮层的灰质损失有关. 这种神经退行,特别是在右轨道前皮层,随着疾病持续时间的延长而恶化.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 感染后嗅觉功能障碍 (PIOD) 在临床实践中是一个重大挑战.
- 了解PIOD潜在的神经病理机制对于开发向治疗至关重要.
研究的目的:
- 为了调查PIOD患者的灰质形态变化.
- 确定导致PIOD嗅觉功能障碍的因素.
- 使用先进的神经成像技术,阐明PIOD的神经病理基础.
主要方法:
- 采用了基于voxel的形态测量 (VBM) 和基于表面的形态测量 (SBM).
- 在46名PIOD患者和46名对照人群中分析了结构性MRI扫描.
- 进行了嗅觉心理物理测试和嗅觉事件相关潜力 (oERP) 检查.
主要成果:
- PIOD患者在右轨道前皮层 (OFC) 中显著减少了灰质体积和皮质厚度.
- 右侧OFC的灰质体积与疾病持续时间有负相关性.
- 在右侧OFC灰质变化和嗅觉测试得分或oERP参数之间没有发现显著的相关性.
结论:
- PIOD与神经退行性变化有关,特别是右侧OFC缩.
- 在右侧OFC观察到的缩随着嗅觉功能障碍的持续时间而进展.
- 这些发现表明,持续的嗅觉障碍与PIOD中的结构性大脑变化之间存在联系.
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