Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

333
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
333
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Exploring foot-based SNARC effect by hand posture: insights from embodied cognition.

Cognitive processing·2026
Same author

Interval Timing Is Altered in Male Nrxn1<sup>+/-</sup> Mice: A Model of Autism Spectrum Disorder.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Mice extrapolate temporal information based on previously learned spatiotemporal mappings: An asymmetrical case.

Learning & behavior·2026
Same author

Bidirectional Interference Between Spatial and Temporal Processing: Evidence From a Distracting Dual-Task Paradigm.

Cognitive science·2025
Same author

Perceptual decision making and metacognition in relation to obsessive-compulsive traits.

Consciousness and cognition·2025
Same author

Psychophysical dissection of temporal error monitoring.

Cognitive processing·2025
Same journal

Vestibular function drives gaze stability in locomoting macaques.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
查看所有相关文章

相关实验视频

Updated: Jan 9, 2026

Author Spotlight: Exploring the Link Between Time Perception of Visual Stimuli and Reading Skills
09:27

Author Spotlight: Exploring the Link Between Time Perception of Visual Stimuli and Reading Skills

Published on: January 19, 2024

1.7K

中脑多巴胺通过值设置扭曲主观时间,但不是时钟速度.

Alihan Erdağı1,2, Ezgi Gür1,3, Fuat Balcı1,4

  • 1Koç University, Research Center for Translational Medicine, Istanbul, Türkiye.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|December 2, 2025
PubMed
概括
此摘要是机器生成的。

在substantia nigra pars compacta中多巴胺神经元活动发生变化的小鼠显示了间隔时间的变化. 调节多巴胺神经元活动调整了时间值,而不是内部时钟速度.

更多相关视频

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia
10:05

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

10.1K
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.3K

相关实验视频

Last Updated: Jan 9, 2026

Author Spotlight: Exploring the Link Between Time Perception of Visual Stimuli and Reading Skills
09:27

Author Spotlight: Exploring the Link Between Time Perception of Visual Stimuli and Reading Skills

Published on: January 19, 2024

1.7K
Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia
10:05

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

10.1K
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.3K

科学领域:

  • 神经科学是一个神经科学.
  • 行为神经科学 行为神经科学
  • 计算神经科学是一种神经科学.

背景情况:

  • 间隔时间是一个基本的认知功能,在各个物种中得到保护.
  • 间隔时间的神经支,特别是多巴胺的作用,仍然不完全理解.
  • 多巴胺功能障碍与神经和精神疾病中的时间缺陷有关.

研究的目的:

  • 阐明尼格罗斯特里亚塔尔多巴胺基神经元在间隔时间的精确作用.
  • 调查多巴胺是否调节内部时钟的速度或计时的决策值.

主要方法:

  • 在雄性小鼠的 substantia nigra pars compacta 中,对氨酸氧酶阳性 (TH+) 神经元进行光遗传学操纵 (激发和抑制).
  • 需要小鼠产生3秒间隔的行为任务.
  • 漂移-扩散-定时模型分析以解释行为数据.

主要成果:

  • 刺激TH+神经元将时间行为转移到更长的时间 (向右转移).
  • 抑制TH+神经元将时间行为转移到更短的时间 (向左转移).
  • 模型分析表明,多巴胺调节改变了时间值,但没有改变时间整合 (时钟速度) 的速度.

结论:

  • 尼格罗斯特里亚特的多巴胺功能在设定间隔时间的门方面发挥着至关重要的作用.
  • 多巴胺影响时间谨慎 (需要多少证据才能做出时间决定),而不是时钟速度.
  • 这项研究提供了对多巴胺在大脑内部时钟中的作用的机制理解.