中脑多巴胺通过值设置扭曲主观时间,但不是时钟速度.
Alihan Erdağı1,2, Ezgi Gür1,3, Fuat Balcı1,4
1Koç University, Research Center for Translational Medicine, Istanbul, Türkiye.
概括
在substantia nigra pars compacta中多巴胺神经元活动发生变化的小鼠显示了间隔时间的变化. 调节多巴胺神经元活动调整了时间值,而不是内部时钟速度.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 间隔时间是一个基本的认知功能,在各个物种中得到保护.
- 间隔时间的神经支,特别是多巴胺的作用,仍然不完全理解.
- 多巴胺功能障碍与神经和精神疾病中的时间缺陷有关.
研究的目的:
- 阐明尼格罗斯特里亚塔尔多巴胺基神经元在间隔时间的精确作用.
- 调查多巴胺是否调节内部时钟的速度或计时的决策值.
主要方法:
- 在雄性小鼠的 substantia nigra pars compacta 中,对氨酸氧酶阳性 (TH+) 神经元进行光遗传学操纵 (激发和抑制).
- 需要小鼠产生3秒间隔的行为任务.
- 漂移-扩散-定时模型分析以解释行为数据.
主要成果:
- 刺激TH+神经元将时间行为转移到更长的时间 (向右转移).
- 抑制TH+神经元将时间行为转移到更短的时间 (向左转移).
- 模型分析表明,多巴胺调节改变了时间值,但没有改变时间整合 (时钟速度) 的速度.
结论:
- 尼格罗斯特里亚特的多巴胺功能在设定间隔时间的门方面发挥着至关重要的作用.
- 多巴胺影响时间谨慎 (需要多少证据才能做出时间决定),而不是时钟速度.
- 这项研究提供了对多巴胺在大脑内部时钟中的作用的机制理解.
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