通过合成生物学实现可定制单细胞蛋白质生产的趋势:碳负生物制造和工程功能
Zhihan Yang1, Lin Li1, Yingli Chen1
1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.
Journal of agricultural and food chemistry
|December 2, 2025
概括
合成生物学通过优化原料,微生物菌株和发酵来推进单细胞蛋白 (SCP) 生产. 这使SCP成为动物料和未来人类食品的可持续蛋白质来源.
科学领域:
- 生物技术是生物技术.
- 合成生物学 合成生物学
- 可持续的粮食生产可持续的粮食生产
背景情况:
- 全球人口增长需要可持续的蛋白质替代品,超越传统农业.
- 单细胞蛋白 (SCP) 是有前途的,但在原料,效率和可扩展性方面面临挑战.
研究的目的:
- 审查合成生物学创新如何解决SCP价值链中的障碍.
- 探索SCP在动物料和人类食品应用中的潜力.
主要方法:
- 检查基质从糖到C1化合物和废物流的演变.
- 分析微生物菌株工程和代谢途径优化方面的进展.
- 研究精密发酵控制和数字集成.
主要成果:
- 工程微生物表现出增强的C1同化能力.
- 代谢工程和理性设计提高了蛋白质生物合成效率.
- 数字化,基于模型的发酵可以实现强大的,可扩展的生物处理.
结论:
- 合成生物学为整个价值链的SCP生产挑战提供了解决方案.
- 在营养方面,SCP可以定制为各种人类食品应用,增强感官接受度.
- 对未来的粮食系统来说,SCP代表了一种多功能和可持续的蛋白质来源.
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