经过乳腺癌手术和瘤后果的重大系统性感染
Linda Adwall1,2, Irma Fredriksson3,4, Hella Hultin3
1Department of Surgery, Division of Breast Surgery, Södersjukhuset, Stockholm, Sweden.
The British journal of surgery
|December 2, 2025
概括
乳腺癌手术后的主要系统性感染增加了远期复发和死亡的风险. 迅速治疗这些术后感染对于改善患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 手术后感染是已知的癌症手术并发症.
- 它们对乳腺癌复发风险的影响尚不清楚.
- 这项研究调查了主要系统性感染和乳腺癌结果之间的联系.
研究的目的:
- 评估乳腺癌手术后重大系统性感染后远程复发的风险.
- 评估与其他主要不良事件 (如中风和心肌梗塞) 的相关性.
主要方法:
- 在瑞典 (2008-2019) 进行了全国性乳腺癌患者队列研究.
- 来自国家注册表的数据,将手术和医疗保健数据联系起来.
- 主要暴露:在手术后90天内发生主要的全身性感染; 主要结局:远期复发.
主要成果:
- 1.8%的患者在90天内出现了主要的全身感染.
- 主要系统性感染与更高的远程复发风险有关 (HR 1.23).
- 观察到增加整体死亡风险 (HR 1.47) 和乳腺癌特定死亡风险 (HR 1.27).
结论:
- 主要的全身性术后感染与远程复发风险的增加有关.
- 这些感染还增加了整体和乳腺癌特定死亡率的风险.
- 强调需要对术后感染进行有效管理.
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