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Luca Filippi¹, Andrea C Luna Mass², Esra Arslan³

¹Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.

Seminars in nuclear medicine

|December 2, 2025

概括

纤维细胞激活蛋白 (FAP) 成像显示在检测细胞癌和膀癌等侵袭性泌尿器官癌症方面具有前途. 与FDG PET相比,FAPI PET提供了更好的瘤可视化,早期放射性体治疗试验显示出积极的结果.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
核医学就是核医学.

背景情况:

纤维细胞激活蛋白 (FAPs) 在瘤微环境中的与癌症相关的纤维细胞中高度表达.
放射性标记的FAP抑制剂 (FAPI) 为其他方式提供了一个补充成像的视角.
FAP的表达与瘤的攻击性,免疫逃避和脏细胞癌 (RCC) 和膀癌 (BC) 的不良预后相关.

研究的目的:

总结目前关于RCC和BC的FAPI成像的证据.
探索FAPI作为这些泌尿器官癌症的诊断剂的实用性.

主要方法:

对RCC和BC中基于FAPI的成像现有证据的系统审查.
临床经验分析,将FAPI PET与[18F]FDG PET进行比较.
对基于FAPI的放射性连接体疗法的早期试验的审查.

主要成果:

与[18F]FDG PET相比,FAPI PET实现了较高的瘤与背景比率,并改善了转移性病变的检测.
尿排泄限制了对FAPI的初级瘤评估,类似于FDG.
基于FAPI的放射性连接体疗法 ([177Lu]FAPI-2286) 的早期试验显示出有希望的安全性和初步疗效.

结论:

FAPI成像是生殖尿道瘤学的一个有前途的工具,特别是用于检测转移.
FAPI为RCC和BC的传统成像提供了一个补充的视角.
需要进一步的前性研究来充分评估基于FAPI的药物的潜力.

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