糖溶性多样性推动了癌症中的免疫复杂性
Cai-Yuan Wu1, Chun-Xiang Huang1, Yuan Wei1
1Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Trends in immunology
|December 2, 2025
概括
瘤免疫微环境 (TIME) 复杂性来自葡萄糖代谢,影响免疫逃避和抗瘤反应. 准葡萄糖代谢通过调节时间,为癌症治疗提供了一个有希望的策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢研究的研究.
背景情况:
- 瘤免疫微环境 (TIME) 是癌症进展和治疗反应的关键决定因素.
- 代谢重编程,特别是葡萄糖代谢,显著影响了TIME的组成和功能.
- 了解瘤内的细胞代谢和免疫反应之间的相互作用,对于开发有效的癌症疗法至关重要.
研究的目的:
- 审查葡萄糖代谢如何塑造瘤免疫微环境 (TIME).
- 探索代谢变化对免疫效应器功能和免疫逃避的影响.
- 突出针对癌症治疗的葡萄糖代谢的治疗策略.
主要方法:
- 文献综述侧重于葡萄糖代谢和瘤免疫微环境.
- 对研究免疫和瘤细胞代谢重编程的研究进行分析.
- 综合当前关于代谢变化对免疫反应影响的研究.
主要成果:
- 葡萄糖代谢决定了免疫和瘤细胞的细胞状态,从而塑造了时间.
- 免疫和瘤细胞中的糖解质多样性有助于时间的复杂性.
- 代谢变化深刻影响免疫效应器功能,并促进免疫逃避.
结论:
- 葡萄糖代谢是瘤免疫微环境的关键调节者.
- 通过代谢干预来调节时间是一个有前途的治疗途径.
- 在癌症治疗中准葡萄糖代谢可以增强抗瘤免疫力,克服免疫逃避.
相关概念视频
Adaptive Mechanisms in Cancer Cells
6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K
Cancers Originate from Somatic Mutations in a Single Cell
14.5K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.5K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Stem Cells and Tumor Maintenance
5.8K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.8K
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Diversity in Cell Signaling Responses
7.6K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
7.6K


