塞特拉林化物暴露导致反应性氧物种在模型微藻物种 (Raphidocelis subcapitata) 中爆发
Phillip J Ankley1, Justin Stewart1, Mackenzie Nash1
1Oak Ridge Institute for Science and Education (ORISE) Research Participant, Great Lakes Toxicology and Ecology Division, US Environmental Protection Agency, Duluth, Minnesota 55804, United States.
Environmental science & technology
|December 2, 2025
概括
选择性血清素再吸收抑制剂 (SSRI),如塞特拉林,可能会损害水生生物. 这项研究揭示了塞特拉林如何通过破坏光合作用来引起微藻中的化,从而提供了对制药生态风险的见解.
科学领域:
- 环境毒理学环境毒理学
- 水生生态毒理学 水生生态毒理学
- 分子生物学分子生物学
背景情况:
- 微藻类是水生污染物评估的重要生态指标.
- 塞特拉林是一种常见的SSRI,在环境相关的度下引起Raphidocelis subcapitata中的化.
研究的目的:
- 估计使用转录组和代谢组起点 (tPOD和mPOD) 的塞特拉林化物潜在危险度.
- 为塞特拉林化物对R的影响提出一个不良结果途径 (AOP). 使用多组学方法的subcapitata.
主要方法:
- 利用转录组和非向代谢组分析来得出tPODs和mPODs.
- 集成的多组学数据,以阐明塞特拉林毒性的分子机制.
- 评估光合作用能力和反应性氧物种 (ROS) 生成.
主要成果:
- 代谢性POD (mPOD) 与转录性POD (tPOD) (455与690μg/L) 是可比的.
- 塞特拉林破坏了光合作用中的循环电子流,导致ROS爆发.
- 观察到细胞膜组成的变化和血红素生物合成途径的下调.
结论:
- 微藻中塞特拉林诱导的化与光合作用中断和氧化应激有关.
- 这项研究证明了将代谢学和转录学整合为药品生态风险评估的实用性.
- 拟议的AOP提供了对水生生物中SSRI生态毒性的机制性理解.
相关概念视频
Channel Rhodopsins
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Red Algae
Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...


