一项针对2型糖尿病的低碳水化合物数字支持减肥计划的随机对照试验
Elizabeth Morris1,2, Jadine Scragg3,4, Richard Stevens3,5
1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. Elizabeth.morris@phc.ox.ac.uk.
NPJ digital medicine
|December 2, 2025
概括
与常规护理相比,数字支持的低碳水化合物减肥计划没有改善2型糖尿病 (T2D) 患者的血糖控制. 最初的减肥在12个月后没有持续,没有显著的好处.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 数字健康数字健康
背景情况:
- 2型糖尿病 (T2D) 的管理通常涉及生活方式干预.
- 数字健康工具为慢性疾病管理提供了可扩展的解决方案.
- 低碳水化合物饮食正在探索它们对血糖控制的影响.
研究的目的:
- 为了评估数字支持的低碳水化合物减肥计划的有效性.
- 为了比较接受干预的T2D患者的血糖控制与通常的初级保健.
- 在12个月内评估HbA1c和心血管风险因素的变化.
主要方法:
- 一个为期12个月的随机对照试验 (RCT) 涉及115名T2D患者 (BMI≥27 kg/m2).
- 参与者被随机分配到一个为期12周的低碳水化合物计划,提供数字支持或通常的护理.
- 主要结局是3个月和12个月的HbA1c与基线的变化.
主要成果:
- 在3个月或12个月的组之间HbA1c变化没有显著差异 (p=0.80).
- 干预组3个月 (2.6公斤) 的体重减轻在12个月 (-0.4公斤) 没有持续.
- 该干预对患者来说是可以接受的,但对血糖或心血管风险因素没有显著影响.
结论:
- 数字化提供的低碳水化合物干预措施对T2D血糖控制没有比常规护理提供额外的好处.
- 干预早期实现的体重减轻并没有长期维持.
- 进一步的研究可能会探索不同的数字策略或饮食方法来管理T2D.
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