更年期和常见的皮肤病:系统性审查
Katie Roster1, Lauren Fleshner2, Turkan Banu Karatas3
1Department of Dermatology, Georgetown University School of Medicine, Medstar Washington Hospital Center, Washington, D.C., USA.
更年期显著影响皮肤状况,如脱发和牛皮,而其对和粉红的影响通常是积极的. 更年期激素治疗 (MHT) 显示出不同的结果,需要进一步的研究.
科学领域:
- 皮肤病学和内分泌学研究.
- 调查女性健康和皮肤状况的交叉点.
背景情况:
- 更年期,雌激素的自然下降,影响皮肤和粘膜的健康.
- 更年期和更年期激素治疗 (MHT) 对慢性皮肤疾病的确切影响尚未完全理解.
研究的目的:
- 探索更年期,MHT和常见的皮肤病之间的联系.
- 综合当前关于更年期状态如何影响各种皮肤疾病的证据.
主要方法:
- 在2024年9月之前对PubMed,Embase和Web of Science数据库进行系统审查.
- 包括40项研究,研究更年期/MHT对脱发症,牛皮,,粉红疹,黑色素瘤和腹炎 (HS) 的影响.
- 提取和综合研究设计,人口,荷尔蒙状况和皮肤学结果的数据.
主要成果:
- 绝经后的脱发,特别是额头纤维化脱发 (FFA) 和女性发型脱发 (FPHL),显示出与更年期的最强联系.
- 牛皮经常在绝经后持续或恶化;和粉红色一般会改善.
- 黑色素结局是混合的,HS反应是不一致的. MHT与增加的FFA和粉红病风险有关,对其他疾病的发现有所不同.
结论:
- 更年期会影响几种慢性皮肤疾病的发展和进展.
- 关于MHT影响的证据有限且不一致,通常基于较旧的配方.
- 针对不同人群和当前的MHT进行进一步的皮肤病专注研究对于个性化患者护理至关重要.
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