肺病理和通风模式的交互作用驱动异质和异型的区域应变力学和异型的区域应变力学
Talyah M Nelson1, Kathrine A M Quiros1, Mona Eskandari2,3
1Department of Mechanical Engineering, University of California, Riverside, CA, USA.
Scientific reports
|December 2, 2025
概括
正压通风 (PPV) 比负压通风 (NPV) 造成更大的肺压力,特别是在患病的肺部,可能导致呼吸器诱导的肺损伤 (VILI). 了解这些差异对于更安全的机械通风策略至关重要.
科学领域:
- 肺动力学 肺动力学
- 生物医学工程 生物医学工程
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 机械通风对于治疗肺部疾病至关重要,但可能导致呼吸器诱导的肺损伤 (VILI).
- 阳性压力通风 (PPV) 与负压通风 (NPV) 相比,可能会增加VILI风险,但机制尚不清楚,特别是在患病的肺部.
- 在病态肺部状态下,PPV与NPV的研究有限.
研究的目的:
- 通过比较PPV和NPV下的局部机械菌株,在健康的,肺的和纤维化的小鼠肺部中研究VILI的机制.
- 将散装肺机械与局部应变分析结合起来,以了解通风模式和疾病相互作用.
- 确定PPV和NPV在各种病理条件下如何不同地影响肺机械.
主要方法:
- 利用定制的电机械设备对ex vivo小鼠肺部 (健康的,质的,纤维化的) 施加PPV和NPV模式.
- 采用数字图像相关性来捕获连续的局部机械应变.
- 集成的局部菌株数据与传统的散装压力-体积肺分析.
主要成果:
- 在所有肺组中,PPV在低到中吸量时诱导的局部应变明显大于NPV,表明过度应变.
- 在PPV下纤维化肺部表现出明显的变形异质性,异质性和剪切菌株,表明放大了损伤.
- 在PPV下的肺瘤肺部显示中央过度扩张,突出了特定的脆弱区域.
结论:
- 与NPV相比,PPV导致较大的局部过度存在和应变,特别是在患病的肺部,有助于VILI.
- 通风模式与肺病理学有显著的相互作用,影响应变分布和损伤途径.
- 结果为优化机械通风策略和开发VILI的预测计算模型提供了洞察力.
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