相关实验视频

Updated: Jan 9, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

在早产婴儿早期干预计划的5至6岁神经发育结果

Camilla Fontana^1,2, Livia Provitera², Chiara Bonfanti³

¹Department of Clinical Sciences and Community Health, Dipartimento Di Eccellenza 2023-2027, University of Milan, Milan, Italy.

Scientific reports

|December 2, 2025

概括

早期干预计划显著改善了早产婴儿的长期神经发育结果. 这些计划,包括家长培训,显示了持续的好处,直到学龄,突出了他们对有风险的儿童的重要性.

科学领域:

新生儿护理和发育儿科.
表观遗传学和发育生物学.

背景情况:

过早分娩与长期的神经发育挑战有关.
早期干预 (EI) 计划旨在缓解这些问题,但长期影响需要进一步调查.
LINE1促进物甲基化是发展结果的潜在表观遗传标记物.

研究的目的:

为了评估早产婴儿在NICU逗留期间参加基于父母的EI计划的长期神经发育结果.
调查与EI相关的LINE1促进体甲基化水平在学龄早期.
评估EI对早产婴儿的持续疗效.

主要方法:

一个随机对照试验 (RCT) 的二次分析,涉及早产婴儿 (25-29周妊娠年龄).
婴儿被随机分配到标准护理 (SC) 或早期干预 (EI),包括父母培训和多感官体验.
神经发育评估 (格里菲斯分数) 和LINE1促进体甲基化分析 (口腔抹布) 在5-6岁时进行.

主要成果:

36名婴儿 (21名EI,15名SC) 完成了随访.
在EI儿童中,一般发育指数得分显著更高 (90.4比82.3,p=0.003).
纵向分析表明,随着时间的推移,EI的益处是持续的和不同的;两组之间没有发现LINE1甲基化显著差异.

结论:

基于家长的早期干预计划表明,对早产婴儿的神经发育有显著和持续的长期益处.
这些发现支持对EI的实施,以改善早产儿的发育轨迹.
需要进一步的研究来探索潜在的机制和优化干预策略.

关键词:

早期干预是早期的干预.早期的学校年龄早期的学校年龄在表观遗传学上,表观遗传学是表观遗传学.第1行一线神经发育神经发育过早出生的婴儿是早产的

更多相关视频

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

Preterm EEG: A Multimodal Neurophysiological Protocol

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

相关概念视频

Socioemotional Development during Infancy

Socioemotional Development during Infancy

Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.