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MAZ通过激活MYB转录来调节胎儿的血红蛋白抑制

Dian Lu1,2, Yinghong Yang1, Bo Yang1

  • 1Department of Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; GMU-GIBH Joint School of Life Sciences, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Scientific reports
|December 2, 2025
PubMed
概括

Myc相关的指 (MAZ) 抑制胎儿血红蛋白 (HbF) 的产生. 削弱MAZ会增加血细胞中的HbF,为治疗状细胞病和β-血症等血红蛋白疾病提供了一个新的标.

关键词:
胎儿血红蛋白 (HbF) 是一个这是一个迷宫,一个迷宫.这就是MYB.状细胞疾病是一种状细胞疾病.在β-thalassemia中,

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