预测因素和血动力学不稳定性在手术期间的血动力学不稳定性,在患有色细胞瘤和偏角细胞瘤的患者
Wenqiang Qi1, Shangzhen Geng2, Yinrui Xiang1
1Department of Urology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Lixia District, Jinan, 250012, Shandong Province, China.
Surgical endoscopy
|December 2, 2025
概括
在手术期间的手术内血动力学不稳定性 (HDI) 通过较大的瘤大小,高血压史,高上腺素和不充分的准备预测. 一个新的名图有助于评估患者的风险,以便更好地管理.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 心血管外科心血管外科
背景情况:
- 在手术期间的血液动力学不稳定性 (HDI) 在染细胞瘤和偏角质瘤 (PPGL) 手术期间构成重大风险.
- 有效的风险分层需要确定HDI的预测因素.
研究的目的:
- 确定手术前内血动力学不稳定性 (HDI) 的独立预测因子,用于手术中患有色细胞瘤和偏角细胞瘤 (PPGLs) 的患者.
- 在PPGL手术中开发和验证用于个性化风险评估的预测性名录,用于手术内HDI的个性化风险评估.
主要方法:
- 对203名PPGL患者的回顾性分析.
- 评估人口统计,临床特征,瘤特征,甲醇胺水平,以及手术前准备的充分性.
- 后勤回归分析以确定独立预测因素.
- 预测名ogram的构建和内部验证.
主要成果:
- 65.5%的患者经历了手术期间的HDI.
- 确定了独立预测因素:最大瘤直径>49.5毫米,手术前高血压史,血上腺素升高,以及手术前准备不足.
- 开发的名图表显示出良好的分辨率 (AUC = 0.823) 和校准.
结论:
- 最大瘤直径,高血压史,血上腺素升高,以及不充分的准备是PPGL手术中手术内HDI的关键预测因素.
- 诺姆图为个性化手术前风险评估提供了一个有价值的工具.
- 这有助于临床医生优化高风险PPGL患者的管理策略.
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