胎儿小鼠大脑发育的性别二态重编程是由母性雌激素过量引起的
Huihui Wang1, Zhe Wei1, Yu Zhang2,3
1Department of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Biology of sex differences
|December 2, 2025
概括
产前高 Estradiol (HE) 暴露改变胎儿大脑发育不同于男性和女性. 这种过多的雌激素会破坏神经前体细胞平衡,特别是在男性中,为神经发育障碍提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 孕期的环境因素会导致性别特定的发育编程,增加疾病的易感性.
- 产前高雌激醇 (HE) 暴露与男性偏向的神经发育障碍有关,但机制尚不清楚.
研究的目的:
- 在小鼠模型中调查性别特异的分子和细胞大脑对妊娠期间高 Estradiol (HE) 暴露的反应.
- 阐明HE诱导的性别二态神经发育改变背后的机制.
主要方法:
- 空间转录组学被用来分析胎儿大脑中的异性基因表达和信号通路.
- 评估了细胞类型识别,体受体相互作用和转录因子活性.
- 免疫光被用来检查神经前代细胞动态.
主要成果:
- 母亲的HE暴露诱导了胎儿大脑中的差异性基因表达,对男性偏差基因的影响更大.
- 观察到特定区域的细胞反应和异性信号通路改变.
- 在男性大脑皮层中,HE暴露破坏了神经前代细胞的增殖-分化平衡.
结论:
- 母性雌激素过量导致胎儿的性别二态大脑重编程.
- 这些发现提供了关于妊娠内分泌干扰和神经发育障碍的机制性见解.
- 建立了针对内分泌干扰剂引起的疾病的干预措施的框架.
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