Hypericum perforatum L. 提取物通过炎症,脂质代谢和铁亡调节来缓解代谢相关的脂肪肝疾病:一个多omics视角
Peng Huang1, Yunling Zhu1, Yidan Qin1,2
1Department of Traditional Chinese Medicine, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China.
Chinese medicine
|December 2, 2025
概括
关叶金锡陶 (GYJST) 通过调节铁,氧化应激,脂质代谢和炎症,有效治疗代谢相关的脂肪肝疾病 (MAFLD). 这项研究揭示了GYJST作为MAFLD的有前途的多目标治疗方法.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
背景情况:
- (Hypericum perforatum L.) (GYJST) 是一种药用植物,具有神经和代谢疾病的潜力.
- 它对代谢相关脂肪肝疾病 (MAFLD) 的影响尚不清楚.
- 这项研究调查了GYJST对MAFLD的治疗潜力.
研究的目的:
- 综合评估GYJST对MAFLD的治疗效果.
- 阐明GYJST在MAFLD的基本监管机制.
- 探索GYJST对铁亡,氧化应激,脂质代谢和炎症的影响.
主要方法:
- 在体内 (HFD诱导的小鼠) 和体内 (PA诱导的AML12细胞) 进行了实验.
- 组织学分析 (H&E,Masson,Sirius Red,Oil Red O,F4/80) 对肝脏病理进行了评估.
- 一种多omics方法 (网络药理学,转录组学,蛋白质组学,代谢组学) 与RT-qPCR,西部涂抹和免疫光阐明的机制集成.
主要成果:
- 通过减少炎症,氧化应激和脂质失调,GYJST证明了对肝损伤的保护作用.
- 网络药理学确定了GYJST的多目标,多途径机制.
- 综合性奥米克分析显示,GYJST调节NF-κB/COX-2和Nrf2/PPARα/g信号通路,抑制炎症,氧化应激,脂质积累和铁.
结论:
- GYJST对MAFLD具有多个目标的治疗效果.
- 它同时通过相互连接的途径调节铁,氧化应激,脂质代谢和炎症.
- GYJST被确定为MAFLD治疗的有前途的治疗候选药物.
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