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基于油和无油配方,以提高大麻的生物可用性

Petr Jelínek¹, Anežka Klouček², Ashley Hannah George¹

¹Department of Chemical Engineering, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Czech Republic.

Journal of cannabis research

|December 3, 2025

概括

通过特定的滴和颗粒大小优化大麻 (CBD) 配方,可显著提高口服生物利用性. 与其他配方相比,中型乳液 (大约16微米) 显示CBD吸收的最有效增加.

科学领域:

药理学和药物输送药理学和药物输送
纳米技术和材料科学材料科学

背景情况:

大麻二醇 (CBD) 具有治疗性质,但由于溶解性差和第一通代谢,其口服生物可用性较低.
乳液和颗粒等配方策略旨在改善CBD溶解和淋巴吸收.
这项研究研究了油滴/颗粒大小和表面活性剂度对CBD口服生物可用性的影响.

研究的目的:

评估配方参数对大麻素 (CBD) 口服生物可用性的影响.
为了比较油基乳液与无油颗粒在增强CBD吸收方面的疗效.
为了确定最佳的配方特性,以改善CBD的输送.

主要方法:

使用膜乳化,高压均质化和溶剂乳化-蒸发来制备CBD乳液和颗粒.
使用显微镜和光散射来表征物理化学性质.
与CBD-日向油溶液相比,在口服各种配方后,对大鼠的药理学参数进行了评估.

主要成果:

与参考油溶液相比,所有测试的配方都改善了CBD的吸收.
中等尺寸的乳液 (大约16微米) 显示了最高的生物可用性增强 (291%的AUC,455%的C).
无油颗粒也增强了吸收,尺寸的影响最小;然而,过度的表面活性剂 (Tween 20,乙) 降低了整体暴露.

结论:

配方设计对于提高口服CBD生物可用性至关重要.
中型乳液提供了最显著的生物可用性改善,而无油颗粒提供了额外的好处.
均衡的表面活性剂度至关重要,以避免对全身暴露的负面影响,指导优化CBD配方开发.

关键词:

在体内研究研究体内研究.生物可用性生物可用性大麻二醇 (Cannabidiol) 是一种这是一种乳液乳液.纳米颗粒纳米颗粒

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