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向CXCL8通过抑制JAK-STAT通路来缓解肠上皮炎症

Xiaolong Wu1, Jialing Wu2, Junmin Xu2

  • 1Department of Gastroenterology, Jieyang People's Hospital, Jieyang, 522000, China. 13927015893@139.com.

European journal of medical research
|December 3, 2025
PubMed
概括

通过激活JAK-STAT通路,CXCL8会加剧小肠炎症. 沉默CXCL8减少炎症并改善细胞存活,但STAT1过度表达逆转了这些好处,突出了CXCL8-JAK-STAT轴作为IBD的治疗点.

关键词:
在CXCL8中,CXCL8是CXCL8.炎症性肠病是一种炎症性肠病.在JAK-STAT路径上.脂聚糖类糖化物 脂聚糖类糖化物支持炎症的调解者.

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