微量元素在抗菌素耐药性动态中的作用
Jinhua Chu1,2,3, Yang Chen1,2,3, Muhammad Haris Raza Farhan1,2,3
1National Reference Laboratory of Veterinary Drug Residues (HZAU), Wuhan, Hubei, China.
Biotechnology and bioengineering
|December 3, 2025
概括
由于金属和纳米颗粒的农业污染,通过改变土壤微生物组和促进基因转移,推动了抗菌素耐药性 (AMR). 重新评估农业实践和监管纳米农业化学品对于减轻这一全球健康威胁至关重要.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球威胁,由农业实践加剧.
- 像金属和纳米颗粒这样的非抗生素剂从肥料,杀虫剂和废物中积聚在土壤和水中.
- 这些污染物对微生物群落施加选择性压力,推动了AMR的演变.
研究的目的:
- 审查农业污染物如何影响微生物群落,促进抗生素耐药性基因 (ARG) 的传播.
- 综合环境压力因素的机制,包括工程纳米粒子 (NP),有助于AMR.
- 突出需要修订农业污染管理战略.
主要方法:
- 文献综述综合了农业系统中AMR环境驱动因素的现有研究.
- 污染物促进的水平基因转移 (HGT) 机制的分析.
- 检查纳米颗粒 (NP) 在促进AMR中的作用.
主要成果:
- 农业环境中的金属 (铜,),金属化物 () 和NP改变了微生物群落的组成.
- 污染物通过多种机制增强抗生素耐药性基因 (ARG) 的水平基因转移 (HGT).
- 具有悖论意义的工程NP的次致命度可能会促进纳米耐药性和对AMR的共同选择.
结论:
- 农业实践造成的环境污染是AMR的主要驱动因素.
- 需要紧急重新评估农业污染管理,包括金属门和纳米农业化学法规.
- 将环境抗菌药物耐药性研究与可持续农业联系起来,对于缓解是必不可少的.
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