相关实验视频

Updated: May 6, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

活性赫索索相关化合物调节肠道微生物群,并改善肠道屏障功能在高脂肪饮食诱导的 NAFLD 在老鼠

Sungjin Eun¹, Jin Woo Kim¹, Daekeun Kwon²

¹Division of Food Technology and Nutrition, Sun Moon University, Asansi, Chungcheongnam-do, Korea (the Republic of).

Molecular nutrition & food research

|December 3, 2025

概括

活性赫索索相关化合物 (AHCC) 改善了非酒精性脂肪肝疾病 (NAFLD) 的老鼠的肠道健康. 补充AHCC调节了肠道细菌,增强了肠道屏障功能,减少了炎症,为NAFLD提供了潜在的治疗策略.

科学领域:

胃肠病学和肝病学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

非酒精性脂肪肝 (NAFLD) 是与肥胖和代谢问题相关的日益严重的全球健康问题.
肠道微生物群失调和肠道屏障功能受损对于NAFLD的发展至关重要.
活性赫索索相关化合物 (AHCC) 对NAFLD相关肠道变化的影响尚不清楚.

研究的目的:

研究AHCC补充剂对肠道微生物群组成和肠道屏障完整性的影响.
在高脂肪饮食诱导的NAFLD大鼠模型中评估AHCC对炎症和氧化应激的影响.

主要方法:

32只老鼠接受了对照饮食,高脂肪 (HF) 饮食或HF饮食,含有2%的AHCC,为期6周.
用测序分析了肠道微生物群的组成.
通过测量Mucin 2 (MUC2) 和紧结蛋白表达来评估肠道屏障的完整性.
评估了结肠,肝脏和全身炎症标志物.

主要成果:

补充AHCC显著改变了肠道微生物群的多样性和组成.
有益细菌如Blautia hansenii和Blautia producta的丰富性在AHCC中增加.
AHCC改善了肠道屏障的完整性,由增加的MUC2表达和趋向于更高的紧密结合蛋白表明.
AHCC可以减少局部和全身炎症.

结论:

补充AHCC可以调节NAFLD大鼠的肠道微生物群.
这些微生物转移与改善肠道屏障功能和减少炎症有关.
通过向肠道失调和炎症,AHCC显示出作为管理NAFLD的治疗剂的潜力.

关键词:

活性体相关化合物活性体相关化合物我们的肠道微生物群.这是一种炎症炎症炎症炎症.肠道屏障的完整性肠道屏障的完整性非酒精性脂肪性肝病是什么?

更多相关视频

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

相关概念视频

Functions of the Gut Microbiota

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...

Gut-Brain Axis

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...