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用LC-MS/MS使用乳牛的肌肉内 gentamicin 在牛奶中的残留物耗尽研究和戒备期

DoHui Kim1, Su Min Nam2, Hyoungjoon Moon2

  • 1Animal Disease Control & Quarantine, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.

Journal of veterinary science
|December 3, 2025
PubMed
概括

一种新的液体染色学-双重质谱法 (LC-MS/MS) 方法准确量化了母牛奶中的 جنت米辛残留物. 三天的禁用期确保了 gentamicin 治疗后牛奶的安全性.

关键词:
药物残留物 药物残留物氨基甘油酸氨基化物.毒品残留物 毒品残留物肌肉内注射,肌肉内注射.液体染色学-质谱学-质谱学

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Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...