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Updated: Jan 9, 2026

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model
10:23

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Published on: November 13, 2012

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利用代谢适应来克服黑色素瘤细胞中达布拉费尼布治疗耐药性的作用

Silvia Eller1, Susanne Ebner1, Carmen Haselrieder1

  • 1Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.

Molecular oncology
|December 3, 2025
PubMed
概括

黑色素瘤中BRAF抑制剂耐药性涉及代谢转变和p66Shc信号受损,导致线粒体损伤和活性氧物种 (ROS) 的增加. 耐药细胞对像PEITC这样的ROS诱导药物敏感.

关键词:
这就是BRAFV600E.达布拉费尼布耐药性 达布拉费尼布耐药性高分辨率呼吸计呼吸计黑色素瘤是一种黑色素瘤.线粒体中的线粒体.p66Shccc 在线阅读

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells06:09

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