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Updated: Jan 9, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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通过生理学基础的药理动力学建模来描述阿皮克萨班的药理动力学:胆汁分泌和人体肝内循环的关键作用

Toshiaki Tsuchitani1, Wen Kou2, Masatoshi Tomi1

  • 1Faculty of Pharmacy, Keio University, Tokyo, Japan.

CPT: pharmacometrics & systems pharmacology
|December 3, 2025
PubMed
概括

胆汁分泌和肠肝循环 (EHC) 显著影响人类的阿皮克萨班清除. 这项研究使用了PBPK模型来确认EHC.

关键词:
在PBPK模型中,艾皮克萨班 (Apixaban) 是一种胆道分泌物 胆道分泌物集群的高斯-牛顿方法.进入肝脏循环中的肝脏循环.

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