运动训练的性别特异性适应:专注于正常压力大鼠的自主调节和氧化应激
Maycon Junior Ferreira1, Guilherme Lemos Shimojo2, Filipe Fernandes Stoyell-Conti3
1Exercise Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.
Physiological reports
|December 3, 2025
概括
有氧运动训练显著改善心血管自主控制,减少氧化应激. 这些好处在雌性大鼠中更为明显,突出了对运动干预措施的性别特异反应.
科学领域:
- 生理学 生理学 生理学
- 运动科学 运动科学
- 心血管健康 心血管健康
背景情况:
- 与性别相关的生理差异影响健康和疾病的结果.
- 了解对运动等干预措施的性别特异反应对于个性化健康策略至关重要.
研究的目的:
- 为了比较有氧运动训练对心血管自主调节和雄性和雌性大鼠的氧化应激的影响.
- 调查运动适应性反应中的潜在性别差异.
主要方法:
- 维斯塔鼠被分为静止和训练有素的雄性和雌性群体.
- 跑步机训练进行了8周 (5天/周).
- 评估了心血管自主调节,动脉压和心脏和脏组织中的氧化应激标志物.
主要成果:
- 运动训练改善了两性人的功能表现,自主控制和氧化应激状态,在女性中观察到的益处更大.
- 与雄性相比,雌性大鼠的抗氧化能力,心脏氧化还原平衡和酸盐度都提高了.
- 血管交感调制与脏脂质过氧化正相关.
结论:
- 与雄性大鼠相比,雌性大鼠在有氧运动训练后,在心血管自主调节和器官特异性氧化特征方面表现出卓越的改善.
- 这些发现强调了在运动生理学研究和应用中将性别视为生物变量的重要性.
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