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在中国,与男性发生性关系的男性每日做准备和事件驱动的做准备坚持
Fei Teng1, Paul A Burns1, Michael A Welsch1
1Department of Population Health Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. Email: fionafayeteng@gmail.com, pauburns@gmail.com, michael.welsch21@gmail.com, bwalker5@umc.edu.
Sexual health
|December 3, 2025
概括
在中国,与男性发生性关系的男性中,每日暴露前预防 (PrEP) 的坚持率高于事件驱动的PrEP. 这一发现对于优化该地区艾滋病毒预防策略至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 临床试验 临床试验
背景情况:
- 在中国,与男性发生性关系的男性 (MSM) 中,艾滋病毒发病率仍然很高.
- 暴露前预防 (PrEP) 是一种有效的艾滋病毒预防策略,但中国的吸收和坚持数据有限.
- 这项研究通过检查中国MSM人口中的PrEP启动和坚持来解决这一差距.
研究的目的:
- 评估中国MSM中PrEP启动和遵守情况.
- 为了比较每日口服PrEP和事件驱动PrEP疗程之间的坚持率.
- 为了确定影响PrEP在这个人群中的坚持因素.
主要方法:
- 来自中国广州和武汉多个地点的PrEP示范项目的3个月数据分析.
- 干预涉及一个移动应用程序和社区参与,以促进艾滋病毒查,降低风险和PrEP.
- 提供了两种PrEP方案:每天的特诺福维尔/emtricitabine (Daily-PrEP) 和事件驱动的剂量 (事件驱动的PrEP).
- 坚持被定义为在过去30天内错过的<5片 (每日PrEP) 或没有错过的剂量 (事件驱动PrEP).
- 单变量和多变量逻辑回归被用于数据分析.
主要成果:
- 927人启动了PrEP,其中650人 (70%) 有3个月的随访数据.
- 在341名每日PrEP使用者中,93%的人报告了良好的坚持.
- 在252名事件驱动PrEP用户中,61.5%报告完全遵守.
- 每日PrEP使用者比事件驱动PrEP使用者报告良好坚持的可能性明显高 (OR=7.28,P<0.0001).
结论:
- 与事件驱动PrEP相比,中国MSM的每日口服PrEP的遵守率显著更高.
- 调查结果表明,每天做准备可能是中国这一群体更有效的策略.
- 建议进行进一步的研究,以评估在中国MSM中长期的PrEP坚持和结果.
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