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Updated: Jan 9, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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针对DESI2作为JAK2-突变白血病的新疗法策略

Husheng Mei1, Wuqiang Wen2, Wenjun Zhang1

  • 1Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 3, 2025
PubMed
概括

研究人员确定DESI2是骨髓增殖性新生瘤 (MPN) 中JAK2-V617F突变的关键调节者. 用化合物WWQ-03-012准DESI2为MPN和二次急性髓性白血病 (sAML) 提供了一个有前途的新疗法.

关键词:
这就是 DESI2 的设计.在JAK2‐V617F突变中.在 MPN MPN MPN 的情况下.降解剂降解剂是一种降解剂.药物耐药性 耐药性 药物耐药性

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