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米特拉:一个开源和跨平台可视化工具箱,用于人类内记录
bioRxiv : the preprint server for biology
|December 3, 2025
概括
米特拉是一个新的工具包,用于从脑内记录的脑活动,如电皮质谱 (ECoG) 和立体EEG (sEEG) 的可视化. 它通过准确地将电极数据映射到标准解剖空间,帮助研究人员分析多个受试者的大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 医疗成像医学成像
背景情况:
- 内电生理学记录 (ECoG,sEEG) 为研究人类大脑功能提供了高时空分辨率.
- 现有的工具往往缺乏系统的学科内部和跨学科分析的综合解决方案,特别是在标准化过程中保留学科特定解剖学.
- 精确的电极定位和可视化对于将个人数据集成到标准化神经成像空间至关重要.
研究的目的:
- 介绍Mithra,这是一款新的工具包,旨在可视化和分析内录音.
- 提供一个统一的框架,解决系统的学科内部和跨学科分析当前工具的局限性.
- 为了使电极精确地映射到标准化的解剖空间,同时保持个体主体解剖学.
主要方法:
- 开发了Mithra,这是一个在Python和MATLAB中实现的跨平台工具包.
- 电极可视化与大脑表面和解剖学注释的整合.
- 支持在普通平均空间 (MNI,FreeSurfer) 中进行定位,并与个体解剖学保持一致.
- 实施皮质表面投影以生成基于活动的高斯热图.
主要成果:
- 米特拉可视化了内电极以及大脑解剖.
- 该工具包支持在标准化空间 (MNI,FreeSurfer) 中精确的电极定位,同时保持个体解剖对齐.
- 它通过皮质投影促进了神经活动的空间热图的生成.
- 米特拉为学科内部和跨学科分析提供了灵活,统一的解决方案.
结论:
- 米特拉为可视化和分析内电生理学数据提供了全面的解决方案.
- 该工具包增强了系统的神经科学研究,通过能够进行主题内和跨主题的强有力的分析.
- 米特拉的功能支持在标准化大脑空间中对神经活动进行先进的映射和空间分析.
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