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Updated: Jan 9, 2026

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
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Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology

Published on: May 3, 2021

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如何微小的序列变化使MFS传送器的机械多样性? 在NarU中出现的Symport的一个原子层次的理由

Tanner J Dean1, Jiangyan Feng2, Diwakar Shukla2,1,3,4,5

  • 1Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

bioRxiv : the preprint server for biology
|December 3, 2025
PubMed
概括

像NarU这样的细菌膜载体的微小序列变化可以显著改变它们的传输机制,从抗载体转换为潜在的同载体活动. 这凸显了微妙的残留物差异如何重编程传送器功能.

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The Significance of Membrane Transport01:44

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Flippase
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One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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