Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

Acta neuropathologica·2026
Same author

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics·2026
Same author

Spatial proteomics profiling reveals oncogene-specific immune niches and prognostic markers in NSCLC.

American journal of respiratory and critical care medicine·2026
Same author

Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery.

Brain : a journal of neurology·2026
Same author

Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study.

Journal of Alzheimer's disease : JAD·2026
Same author

Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer's disease.

Acta neuropathologica·2026

相关实验视频

Updated: Jan 9, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

空间多学科工作流程和阿尔茨海默氏症神经病理学分析指南.

Xuehan Sun1, Hannah R Hudson1, Timothy C Orr1

  • 1Department of Neurology, Washington University School of Medicine in St Louis, MO, USA.

bioRxiv : the preprint server for biology
|December 3, 2025
PubMed
概括

一个新的空间生物学管道分析了组织中的全转录组和蛋白质数据. 这一框架确保了阿尔茨海默氏症和ALS等复杂疾病的可重复结果.

更多相关视频

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.3K
Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

17.3K

相关实验视频

Last Updated: Jan 9, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.3K
Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

17.3K

科学领域:

  • 空间生物学 空间生物学
  • 基因组学就是基因组学.
  • 蛋白质组学是指蛋白质组学.
  • 神经科学是一个神经科学.

背景情况:

  • 空间生物学技术提供了高维组织分析.
  • 标准化分析框架对于数据质量和可重复性至关重要.
  • 现有的平台需要强大的方法来解释多原子数据.

研究的目的:

  • 为 GeoMx 数字空间分析仪提供一个端到端的管道.
  • 为了同时从用户定义的组织区域进行全转录组和蛋白质测量.
  • 建立可重复空间多原子分析的准则.

主要方法:

  • 开发了一种整合的工作流程,用于形态学引导的区域选择,质量控制和规范化.
  • 将管道应用于来自阿尔茨海默氏症,勒维体痴呆症,肌缩性侧面硬化症和对照的甲胺固定皮质组织.
  • 利用多模式数据解释进行转录和蛋白质分析.

主要成果:

  • 该框架解决了复杂组织中空间上不同的分子域.
  • 转录和蛋白质信号在病理区域 (例如,粉样斑块) 中显示出差异.
  • 根据疾病状况,RNA-蛋白质一致性有所不同,单个神经元分析表明了蛋白质测定灵敏度.

结论:

  • 这一数据集是空间多原子分析的验证资源.
  • 该管道为可靠和可复制的组织分析提供了广泛适用的指导方针.
  • 这种方法增强了对疾病中的分子和细胞组织的理解.