患有多动症的青少年的结构性连接的发育偏差可以预测症状和治疗结果
bioRxiv : the preprint server for biology
|December 3, 2025
概括
注意缺陷/多动障碍 (ADHD) 缺乏生物标志物. 这项研究在患有多动症的年轻人中发现了结构连接性 (SC) 偏差,这可能作为跟踪症状和指导治疗选择的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 生物标志物 生物标志物
背景情况:
- 青少年注意力缺陷/多动症障碍 (ADHD) 缺乏用于症状跟踪和治疗指导的有效化生物标志物.
- 了解ADHD的神经发育基础对于推进精准医学至关重要.
研究的目的:
- 识别和验证结构连接性 (SC) 偏差作为患有ADHD的年轻人的发育生物标志物.
- 调查SC偏差对ADHD的预后和预后相关性.
主要方法:
- 从规范性与年龄相关的白质SC轨迹的量化个体偏差在两个大,独立的队列 (ABCD和中文).
- 利用纵向的个体内分析来追踪 SC 偏差随时间变化的变化.
- 评估了基线SC偏差的预测值,以评估对阿托莫克西和甲基酸盐的治疗反应.
主要成果:
- 患有ADHD的年轻人表现出明显的SC偏差,特别是在更高阶关联通路中.
- 观察到SC偏差的ADHD特异性发育性减少,调解与年龄相关的症状下降.
- 在两年内,SC偏差的减少与症状改善相关.
- 基线SC偏差预测了对atomoxetine的治疗反应,但不是甲基酸.
- 治疗导致SC偏差的减少.
结论:
- 结构连接性 (SC) 偏差是ADHD的强有力的发育生物标志物,具有预后和预后潜力.
- SC偏差可以通过使风险分层,个性化药物治疗选择和客观的治疗监测来支持精确护理.
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