药物诱导的脂症作为抗病毒药物重用中的一个工件
Isabella S Glenn1, Lu Paris1, Alex D White1
1Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California 94143, United States.
bioRxiv : the preprint server for biology
|December 3, 2025
概括
用于抗病毒发现的药物重新定位受到脂症的阻碍,这是一个有毒的效应. 一种新的快速测定方法在65%的测试药物中发现了这种人工物,包括非离子两性药物,改善了候选药物选择.
科学领域:
- 药物的发现和开发.
- 毒理学 毒理学 毒理学
- 病毒学 病毒学
背景情况:
- 药物重用加速抗病毒的发展,但可以被药物诱导的毒性所混.
- 阴阳性两性药物 (CAD) 显示抗病毒活性,但可能导致脂症,这是一种复杂查的工件.
- 目前用于检测脂症的现有方法是繁且耗时的.
研究的目的:
- 开发一种基于微板的快速测定方法,用于检测脂症.
- 在抗病毒重定向幕中量化诱发脂症的药物的患病率.
- 为了识别超出CAD的潜在的新类型的脂诱导体.
主要方法:
- 开发一种新的,高通量微板测定法,用于检测脂症.
- 对40种药物进行查,报告了微分子抗病毒活性.
- 脂诱导化合物的鉴定和表征.
主要成果:
- 新的测定方法可以有效检测脂症.
- 在测试的药物中,有65% (26分之40) 的药物在与其抗病毒活性相似的度下诱导了脂症.
- 四种非CAD被确定为脂诱导剂,扩大了这种毒性的已知化学空间.
结论:
- 轻松检测脂症检测的测定对于准确的抗病毒药物重新定位至关重要.
- 脂化是抗病毒药物查中常见的人工物,影响CAD和其他药物类别.
- 这项工作有助于防止误导性结果,并专注于真正的抗病毒候选者.
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