对人类肠道微生物组的毒性因成分而异
Carmen E Perez Donado1,2, Sujun Liu1,2, Javier Seravalli3
1Department of Food Science & Technology, University of Nebraska-Lincoln, Lincoln NE, USA.
bioRxiv : the preprint server for biology
|December 3, 2025
概括
暴露对肠道微生物群的影响在个体之间不同. 一些微生物群是敏感的,表现出减少的酸盐和增加的酸盐/乳酸盐,而弹性微生物群保持稳定性,突出表现出对有毒重金属的独特反应.
科学领域:
- 微生物学 微生物学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- (Cd) 是一种有毒的重金属.
- 暴露于CD会对肠道微生物群产生负面影响.
- 了解个体微生物对Cd的反应至关重要.
研究的目的:
- 调查急性Cd暴露对人类便微生物群的组成和功能影响.
- 将微生物对Cd的反应分类为敏感,中等或弹性.
- 为了确定与Cd敏感性或弹性相关的微生物属和相互作用.
主要方法:
- 在实验室内化了来自21名健康成年人的人类便微生物群.
- 暴露于 (Cd) 和控制条件.
- 分析短链脂肪酸生产 (黄酸,酸,乳酸),微生物组成 (加权UniFrac) 和微生物相互作用网络.
主要成果:
- 根据酸盐的生产,确定了三种不同的微生物对Cd的反应类别 (敏感,中等,弹性).
- 在Cd压力下,敏感的微生物组显示酸盐减少,乙酸盐/乳酸盐产量增加.
- 与敏感微生物组相比,弹性微生物组保持了酸盐水平,并减弱了乳酸盐的增加,与敏感微生物组相比,构成转移和相互作用中断较少. 在Cd暴露后的敏感微生物群中, * Anaerostipes * 丰度显著更高.
- 在弹性社区中,酸盐生产与*Faecalibacterium* (Cd-缺失) 和*Anaerostipes* (Cd-存在) 有关.
结论:
- 肠道微生物对急性暴露的反应在个体之间有很大的差异.
- 显著的功能和组成变化是敏感微生物组与弹性微生物组的特征.
- 基底的敏感性或弹性微生物群特征需要进一步调查.
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