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Updated: Jan 9, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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癌症相关的SPOP突变体的系统性表征揭示了新的和可重编程的降解性活动

Alana G Caldwell1, Harshil Parmar2, Xiaokang Jin2

  • 1Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, Illinois 60208, United States.

bioRxiv : the preprint server for biology
|December 3, 2025
PubMed
概括

前列腺癌中斑点型POZ蛋白 (SPOP) 突变显示了基质依赖的功能损失. 这些SPOP变体可以重新用于向的蛋白质降解疗法.

关键词:
E3 结合酶的使用蛋白质与蛋白质的相互作用蛋白质组学是指蛋白质组学.经常发生的突变.有针对性的蛋白质降解降解.

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